With three files (fluid.html, bootstrap.css, and bootstrap-responsive.css) I have the Twitter Bootstrap fluid page layout for consideration for a new squeak.org homepage. [1] No need to worry about responsive design, this page does it for you. I tested it in iPad/iPhone [1] [2] and it comes up looking good each time. Bootstrap is pretty nifty.
Chris
[1] http://www.osrcon.ca/fluid.html [2] http://iphonetester.com/ [3] http://ipadpreview.com/